Page 2Tennessee Association of Drug Court Professionals
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The increasing prevalence of chronic pain continues to be a source of concern for healthcare providers. Health care profession-als have long recognized the potential for addiction and abuse of prescription opioids. In the past decade, a greater focus has been placed on pain management, which has led to a significant increase in the number of opioids prescribed and may have contributed to long-standing trends of abuse and addiction. A dichotomy exists in the realm of pain management between balancing the under-treat-ment of pain and the potential for opioid misuse. One of the treatments of choice for chronic pain involves strong medications such as opioids. Side effects of opioids include seda-tion, dizziness, nausea, vomiting, and constipation. These medica-tions often result in abuse, misuse, or diversions. Adding to the complexity of managing pain patients is the fact that these medica-tions are controlled substances and cannot be purchased over the counter, therefore have high street value. For all these reasons phy-sician are required to determine whether patients under their care are compliant with their medication regime, abusing their medica-tions, or diverting them for financial gain. Thus, managing pain patients with opioid therapy is a difficult and controversial issue.Urine drug testing (UDT) is one of the tools that clinicians use to monitor “medication behaviors” and avoid morbidity and mor-tality associated with opioids. UDT gives confidence to the physi-cian that the patient is following the medication regimen and is therefore getting the most benefit from their treatment. In addi-tion, UDT has been associated with forensic testing, often referred to as workplace testing, to detect illicit drug use in employees. Workplace UDT has traditionally focused on identifying the use of abused drugs including amphetamines (methamphetamine), cocaine, marijuana, phencyclidine (PCP), and heroin (opiates). Proposed Revisions to Testing for these drugs usually follows scheduled guidelines established by the Substance Abuse and Mental Health Services Administration (SAMHSA) (Federal Register, 2004). Analytically, the testing involves qualitative and semi-quantitative immunoassay screening followed by confirma-tion by mass spectrometry. Testing for patients on chronic opioid therapy is a different paradigm as both positive and negative results are important. Assays that are more sensitive and can determine both the parent drug and one or more of its metabolites are there-fore as important.In order for the physicians to have an exact indication of the medications the patients need to take a broader clinical laboratory UDT menu to accurately monitor the pain patient population. For example, a positive opiate test does not indicate whether the patient is on codeine, hydrocodone, morphine, or hydromorphone. Therefore, in order to establish compliance it is necessary for the physician to determine exactly which medication has been ingested and assure the patient is not taking additional opiates which could create an unsafe situation. The medications most commonly found in the urine of this population are clearly hydrocodone and oxycodone, followed by morphine and hydromorphone; codeine is not frequently prescribed for this population. Benzodiazepines are the next most prescribed group. Other opioid medications such as fentanyl, meperidine, tra-madol, and propoxyphene are less frequently used. The use of muscle relaxants, such as carisoprodol, are also commonly seen. Marijuana is by far the most prevalent among the illicit drugs, fol-lowed by cocaine and methamphetamine. The accurate interpreta-tion of test results thus requires an understanding of the usefulness and limitations of immunoassays, knowledge of opiate metabolism, and awareness of the expected ratios of the parent drug and its metabolites in urine. In addition, small amount of impurities in medications detectable by mass spectrometry can complicate the interpretation of UDT results. There are two aspects of drug abuse in the pain patient popula-tion; one is the use of illicit drugs, and the other more prevalent aspect is abuse of the prescribed and non-prescribed medications. Combined, these two facets of abuse may approach 20-30% of the patients on chronic opioid therapy. Based on this data alone, the use of UDT should be justified for pain patients. When monitoring for opioid medication compliance, the testing method should be able to differentiate between codeine, morphine, hydrocodone, norhydrocodone, and hydromorphone. The immunoassay test should also be able to differentiate between oxycodone, noroxyco-done, and oxymorphone. This will allow the physician to determine that the opiate the patient is taking is in fact the one being pre-scribed and that the patient is metabolizing the medication proper-ly. The most commonly abused opioid is hydrocodone, a frequent-ly prescribed pain medication. Hydrocodone is a semi-synthetic opioid prescribed for pain management and cough. It is the most commonly abused prescribed opioid, as determined by the data reported to the American Association of Poison Centers and DAWN. The increased incidence of deaths attributed to hydroco-done abuse is also a major concern. The International Narcotics Control Board reported that 99% of the worldwide hydrocodone supply in 2007 was consumed in the United States. Commercial hydrocodone preparations are always combined with another medi-cation to increase efficacy and reduce adverse effects. It is avail-able as a mixture with acetaminophen (Vicodin), aspirin (Lortab), ibuprofen (Vicoprofen) and antihistamines (Hyconine). Currently, four pharmaceutical companies are developing long acting formu-lations of hydrocodone. Of these, Zohydro ER® has been submit-ted to FDA for new drug consideration. The recommended starting therapeutic dose range for hydrocodone is 5–30 mg (one capsule) per day. Analgesic action of hydrocodone begins 20–30 minutes after taking it and lasts 4–8 hours. Hydrocodone is sometimes referred to as a “pro-drug” because the more active compound is the metabolite (hydromorphone), not the administered drug. Although, several specific immunoassays for drugs of abuse are commercially available, including an opiate immunoassay which detects several opioids simultaneously, its sensitivity to detect hydrocodone and its metabolites is much lower. This leads to increasing possibility of negative screening when the drug is pres-ent in urine. The objective was thus, to develop a specific homoge-neous enzyme immunoassay for the specific detection of hydroco-done and hydromorphone and its glucuronide in human urine.Thermo Fisher Scientific now offers the Thermo Scientific™ DRI® Hydrocodone/ Hydromporphone Immunoassay* with a 300 ng/mL cutoff and ± 25% Low and High Controls. The assay uses a highly specific monoclonal antibody that can detect hydrocodone, hydromorphone and hydromorphone -D-glucuronide. The assay range is 0 ng/mL to 1000 ng/mL. The reagents, calibrators and controls are liquid ready-to-use. The assay demonstrated 100% cross-reactivity to hydromor- phone and its glucuronide with minimal cross-reactivity to opiate compounds and other concomitantly taken drugs. No significant interference was observed from endogenous substances. Two hun-dred and sixty eight patient samples were tested by immunoassay and the results showed >90% agreement with LC-MS/MS.The assay is intended for the qualitative and semi-quantitative determination of hydrocodone and its metabolites in human urine and is compatible with most automated clinical analyzers. For more information about this product and other drugs of abuse immunoassays, go to www.thermoscientific.com/dignostics
Zohydro™ ER is a trademark of Zogenix, Inc. “Vicodin” is a registered trademark of Abbvie Inc. Corporation. “Lortab” is a registered trademark of UCB Pharma Inc. All other trademarks are the property of Thermo Fisher Scientific and its subsidiaries. * For Criminal Justice and Forensic Use Only and is for sale in the U.S.A. only. Author Wendy LocklinCommercial Marketing Manager Thermo Fisher Scientific
As we look forward to the Thanksgiving Session we wanted to share our gratitude with our community. We issued a challenge to our participants to do a “random act of kindness to a stranger”. Our folks did an amazing job and received blessings from their actions. As I tell our partici-pants all the time, they are no longer “jail material”. Our folks are great neighbors, friends, parents, employees and spouses. Here are their accounts of there “act of kindness”:
“I bought a man and woman some cold cuts from wal-mart because I saw them holding up a sign saying they were hungry. I also bought their dog some food!
Michael R. Phase 3
“I gathered up some of the clothes that my daughter can’t wear anymore and some jackets and donated them to our local Mustard Seed. It was a humbling experience for me. I also paid for a lady’s food behing me at McDonald’s.”
Tracy M. Hopeful candidate
“I donated clothes to our Helping Hands and Twice Blessed. I feel so good when I help another. I gave a co-worker a ride home who was waiting in the cold. I gave $16.00 to the Charlie Brown Fund, he is at Vanderbilt Hospital.”
Eden H. Phase 2
“Me and my dad were on our way to Milan and I stopped to help a lady who had a flat. So I changed it for her. It made me feel good”
Bradley W. Phase 2
“I went to Humboldt Wal-mart and helped an elderly couple put their groceries in their car. I told them I was in Recovery Court and now just want to help others.”
Zach E. Phase 2
“I stopped to help a lady who had a flat tire. She said I was the first one to stop and she had been there 45 min-utes.”
Lynn R. Phase 2
“ I work at Butt’s Food and we have homeless people up and down our street. I took a homeless man (John) to the Dodge Store bought him breakfast and found out he was an alcoholic so I gave him a copy of meetings in our area."
Kelsha R. Phase 3
“ I saw a homeless man at Little General in Humboldt and it was cold and raining. I went into the store and bought him a pack of smokes and gave it to him with a 10.00 bill. I hope he is ok today.”
Travis B. Phase 3
“ On my way to the AA meeting I gave a man a ride. I do this often and he don’t talk in the meeting but does on the way back home. It helps us both.”
Bryan C. Phase 2
“I gave my daughter clothes she couldn’t wear to this man’s granddaughter."
Katie W. Phase 4
“A woman who was dropped off at a meeting didn’t have a ride home. I gave her one. It felt good."
Sam G. Phase 3
“I donated my clothes I can’t wear. I’ve gained 27 pounds.”
Kim R. Phase 1
“I went into our local Dollar Store and a cashier named Sam was so kind to me. She mentioned she also had children. She was such a blessing to me I decided to help her. I went home and made a basket full of cookies, fruit etc and wrote her a note took it back to the store and left it at the register with her name on it. It was amazing to share this with my kids”
Mandi L. Phase 1. PS: this girl makes awesome baskets.
“I was riding down the road with my mom and noticed a woman ran her car off in a ditch. We stopped and I went to check on her and stayed with her until the police and ambulance got there.”
Cynric P. Phase 1
THE WORLD DOES NOT CHANGE BY GRANDJESTURES BUT SIMPLE ACTS OF KINDNESS.
Submitted by: Lori; Angie; Monica; Janice; Tom; Scott; Danny (Team Members)
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VENTS
Mark Your Calendars!
2015 NADCP Conference
December 2-4, 2015
Embassy Suites & Conference CenterMurfreesboro, Tennessee
Registration Information Coming Soon!